CKD-519

CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor, which inhibits CETP-mediated transfer of cholesteryl ester in human serum with an IC50 of 2.3 nM[1].

Product Specifications

CAS Number

[1402796-27-3]

Product Name Alternative

WX-UK1; UKI-1C

UNSPSC

12352005

Target

CETP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ckd-519.html

Concentration

10mM

Purity

98.29

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

C[C@H]1[C@H](OC(N1CC2=C(C3=C(C=C(C(C(C)C)=C3)F)OC)CCC(C)(C2)C)=O)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

Molecular Formula

C31H34F7NO3

Molecular Weight

601.60

References & Citations

[1]Kim CO, et al. Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects. Drug Des Devel Ther. 2016 Nov 15;10:3763-3770.