Primidone

Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent[1][2][3].

Product Specifications

CAS Number

[125-33-7]

UNSPSC

12352005

Hazard Statement

H302, H351

Target

GABA Receptor; Necroptosis; RIP kinase; Sodium Channel; TRP Channel

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/primidone.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(C1(CC)C2=CC=CC=C2)NCNC1=O

Molecular Formula

C12H14N2O2

Molecular Weight

218.25

Precautions

H302, H351

References & Citations

[1]Krügel U, et al., Primidone inhibits TRPM3 and attenuates thermal nociception in vivo. Pain. 2017 May;158 (5) :856-867.|[2]Riebeling T, et al., Primidone blocks RIPK1-driven cell death and inflammation. Cell Death Differ. 2021 May;28 (5) :1610-1626.|[3]Vogelnik Žakelj K, et al., Mechanisms of tremor-modulating effects of primidone and propranolol in essential tremor. Parkinsonism Relat Disord. 2024 Nov;128:107151.