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Mahanine

Mahanine is a natural alkaloid that induces apoptosis in leukemia U937 cells via mitochondrial membrane permeabilization and caspase-3 activation. It also acts as an epigenetic modulator in prostate cancer by inhibiting DNMT activity, leading to RASSF1A reactivation and cyclin D1 downregulation, highlighting its potential for cancer research.

Product Specifications

CAS Number

28360-49-8

Field of Research

Infectious Disease & Virology

Smiles

CC (C) =CCC[C@@]1 (C) Oc2c (C) cc3c ([nH]c4cc (O) ccc34) c2C=C1 |wU:6.6, wD:6.5, c:27, (12.99, -4.96, ;11.75, -4.04, ;10.34, -4.65, ;11.93, -2.51, ;10.7, -1.59, ;10.88, -.06, ;9.65, .86, ;10.77,1.91, ;8.8,2.15, ;7.26,2.06, ;6.42,3.35, ;7.11,4.72, ;4.88,3.26, ;4.19,1.88, ;5.03, .59, ;4.07, -.61, ;2.63, -.06, ;1.26, -.77, ; -.04, .06, ; -1.4, -.64, ; .04,1.6, ;1.41,2.31, ;2.7,1.48, ;6.57, .68, ;7.42, -.61, ;8.95, -.52, ) |

Molecular Formula

C23H25NO2

Molecular Weight

347.458

Storage Conditions

-20°C

Notes

For research use only.

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