Anti-C5aR [32-G1]
Product Specifications
Gene Name
[C5aR]
NCBI Gene ID
728
Reactivity
Human
Storage Conditions
Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.
Specificity
The 32-G1 antibody recognizes C5aR which has its serine 334 phosphorylated. The mAb 32-G1 reacted specifically with a C5aR peptide that contained phosphoserine 334 and also reacted with C5aRs that were isolated from C5a-stimulated, transfected RBL-C5aR cells. It did not Recognise a receptor mutant (C5aR-S-) with alanine replacement of all six C-terminal serine phosphorylation sites (Pollok-Kopp et al., 2007). Antibody 32-G1 specifically reacts with C5aR phosphoserine 334, independent of the phosphorylation state of the neighboring serine residues (Pollok-Kopp et al., 2007). Studies with Bt2cAMP-treated U937 cells show that 32-G1 specifically reacts with ligand-activated C5aR at endogenous receptor expression levels but only weakly recognizes C5aR isolated from unstimulated cells (Pollok-Kopp et al., 2007).
Other Gene Names
[C5AR1; C5AR1; C5A; C5AR; C5R1; CD88; C5AR; C5R1; C5a-R; C5aR]
Short Name
[C5aR]
Other Product Names
[C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor; C5a-R; C5a ligand; C5a anaphylatoxin receptor; complement component 5 receptor 1; complement component 5a receptor 1]
NCBI GI Number
4502509
NCBI Accession Number
NP_001727.1
NCBI GB Accession Number
NM_001736.3
Uniprot Accession Number
P21730
CAS Number
9007-83-4
Available Sizes
Curated Selection
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