Anti-Podoplanin (MAP tag) [PMab-1]

Product Specifications

CAS Number

9007-83-4

Gene Name

[PDPN]

NCBI Gene ID

14726

Reactivity

Mouse

Storage Conditions

Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.

Specificity

This antibody is specific for amino acids 38-51 (GDGMVPPGIEDKIT) of the platelet-aggregation-stimulating (PLAG) domain of mouse podoplanin (PDPN). This antibody, therefore, possesses high affinity and specificity for the MAP epitope tag (GDGMVPPGIEDK), which is derived from the PLAG domain of murine podoplanin. PDPN is a type I transmembrane protein that interacts with the platelet receptor C-type lectin-like receptor-2 (CLEC-2). PDPN is expressed by a wide variety of cells, including podocytes, lymphatic endothelial cells and type I alveolar cells. PDPN is also upregulated on certain cancer cells, where it mediates tumour-induced platelet aggregation by binding to CLEC-2 on platelets. Chihara (2018) associated Podoplanin with a co-inhibitory receptor in T-cell activation along with PD-1, TIM-3, LAG-3 and TIGIT.

Other Gene Names

[Pdpn; Pdpn; T1a; Gp38; OTS-8; T1alpha; RANDAM-2; T1-alpha; Gp38; Ots8; Gp38; T1A]

Short Name

[Podoplanin]

Other Product Names

[podoplanin isoform 2; Podoplanin; podoplanin; podoplanin; Aggrus; Glycoprotein 38; Gp38; OTS-8; PA2.26 antigen; T1-alpha; T1A; Transmembrane glycoprotein E11]