Anti-Tim-4 [5G3]

This antibody is specific for murine TIM-4, which unlike other TIM family members, is not expressed on T lymphocytes but rather found on antigen presenting cells such as lymphoid and myeloid DC's and macrophages. TIM-4 has been shown to interact with TIM-1 thereby suggesting a role of TIM-4 in the balance of Th1/Th2 regulation. Additionally TIM-4 has been shown to be a receptor for phosphatidylserine and may play a role in engulfment of apoptotic cells.

[T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin and mucin domain-containing protein 4; Spleen, mucin-containing, knockout of lymphotoxin protein; SMUCKLER; T-cell immunoglobulin mucin receptor 4; TIM-4; T-cell membrane protein 4]