Anti-Fas [R-125224]

Product Specifications

CAS Number

9007-83-4

Gene Name

[Fas]

NCBI Gene ID

355

Reactivity

Human

Storage Conditions

Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.

Specificity

R-125224 binds to the extracellular portion of human Fas at an eptiope consisting of the sequence RTQNTKCRCK (aa 105-114) (pmid: 11754745). Fas is a type I membrane protein which belongs to the tumor necrosis factor (TNF) receptor/nerve growth factor (NGF) receptor superfamily. It is able to transduce apoptotic signals into the cell when bound by its ligand FasL (Fas ligand), which is primarily expressed in activated T lymphoid-myeloid lineage cells, in the eye, in reproductive organs and in some tumors. The Fas-FasL system is known to play an important role in maintaining the immune system as mice with Fas-defective lymphoproliferation (lpr) and FasL-defective generalized lymphoproliferative disease (gld) mutations develop massive lymphadenopathy and autoimmune diseases.

Other Gene Names

[FAS; FAS; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; APT1; FAS1; TNFRSF6]

Short Name

[Fas]

Other Product Names

[tumor necrosis factor receptor superfamily member 6 isoform 1; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; Fas cell surface death receptor; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD_antigen: CD95]