Anti-CD40 [5D12]
Product Specifications
Gene Name
[CD40]
NCBI Gene ID
958
Reactivity
Cynomolgus, Marmoset Monkey, Human
Storage Conditions
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Specificity
ch5D12 binds specifically to recombinant and native human CD40 ectodomain and has been shown to also bind CD40 in cynomolgus and marmoset monkeys. The antibody requires residues within D1 and D1/B2 for binding (Hager et al, 2003) (D1 domain is crucial for CD40L binding). Binding characteristics are very similar between humanized ch5D12 and mu5D12. CD40 is a glycoprotein of the TNFR superfamily and is expressed on all mature B cells, dendritic cells, activated monocytes, some endothelial cells and some epithelium including the thymus. CD40 binds to CD40L, and this interaction is involved in B-cell activation and proliferation, antigen-presenting cell (APC) activation, initiation of antigen-specific T-cell responses, immunoglobulin production, activation of effector macrophages isotype switching, homotypic adhesion and rescue from apoptosis.
Other Gene Names
[CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5]
Short Name
[CD40]
Other Product Names
[tumor necrosis factor receptor superfamily member 5 isoform 1; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily member 5; CD40 molecule; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40]
NCBI GI Number
4507581
NCBI Accession Number
NP_001241.1
NCBI GB Accession Number
NM_001250.5
Uniprot Accession Number
P25942
CAS Number
9007-83-4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
