Tirabrutinib
Tirabrutinib (GS-4059/ONO-4059) is an orally bioavailable, covalent Bruton's Tyrosine Kinase (BTK) inhibitor (IC50 = 6.8 nM) capable of crossing the blood-brain barrier. It suppresses aberrant B-cell receptor signaling and is utilized in research for B-cell malignancies like Waldenström's macroglobulinemia and autoimmune disorders, with applications in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1351636-18-4
Product Name Alternative
Tirabrutinib, Velexbru, ONO 4059, ONO4059, ONO-4059, GS4059, GS-4059, GS 4059, BTK
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.64% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.26 mM) ; DMSO:90 mg/mL (198.03 mM)
Smiles
CC#CC (=O) N1CC[C@H] (C1) n1c2ncnc (N) c2n (-c2ccc (Oc3ccccc3) cc2) c1=O
Molecular Formula
C25H22N6O3
Molecular Weight
454.48
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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