Heparan Sulfate

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

Product Specifications

CAS Number

[9050-30-0]

UNSPSC

12352211

Hazard Statement

H302, H317, H332

Target

Endogenous Metabolite; FGFR; Wnt

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Heparan_Sulfate.html

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=S(OCC1O[C@@H](OC)[C@H](NS(=O)(O)=O)[C@@H](OS(=O)(O)=O)[C@H]1O[C@@H]2OC(C(O)=O)[C@H](O[C@@H]3OC(COS(=O)(O)=O)[C@H](O[C@@H]4OC(C(O)=O)[C@H](OC)[C@H](O)[C@H]4OS(=O)(O)=O)[C@H](O)[C@H]3NS(=O)(O)=O)[C@H](O)[C@H]2O)(O)=O.[n]

Molecular Formula

C12H19NO20S3 (monomer)

Molecular Weight

593.47 (monomer)

Precautions

H302, H317, H332

References & Citations

[1]Kraushaar DC, et al. Heparan sulfate: a key regulator of embryonic stem cell fate. Biol Chem. 2013 Jun;394 (6) :741-51.|[2]Sarrazin S, et al. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011 Jul 1;3 (7) . pii: a004952.|[3]Yamamoto S, et al. Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305 (3) :G241-9.|[4]Minge D, et al. Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex. 2017 Feb 1;27 (2) :903-918.|[5]Gómez-Pinilla F, et al. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. J Neurosci. 1995 Mar;15 (3 Pt 1) :2021-9.