Protein kinase inhibitor 8
Protein kinase inhibitor 8 (Compound CK59) is a calmodulin-dependent protein kinase II (CaMKII) inhibitor. By inhibiting the activity of CaMKII, Protein kinase inhibitor 8 can attenuate the cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and alleviate the downregulation of GLT-1 expression caused by PFOS, thereby reducing neuronal damage. Protein kinase inhibitor 8 may be useful in research related to neurodegenerative diseases[1][2].
Product Specifications
CAS Number
926319-75-7
UNSPSC
12352005
Target
CaMK
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/protein-kinase-inhibitor-8.html
Smiles
O=C(OC(C)(C)C)NCCCCCCNC1=C2N=CN(C(C)C)C2=NC(NCCO)=N1
Molecular Formula
C21H37N7O3
Molecular Weight
435.56
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CaMK II
Frequently Asked Questions
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