PHF6 (TFA)
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein[1].
Product Specifications
UNSPSC
12352209
Target
Amyloid-β; Autophagy
Type
Peptides
Related Pathways
Autophagy; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/phf6-tfa.html
Purity
99.45
Solubility
H2O : ≥ 50 mg/mL
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C36H60N8O9.xC2HF3O2
Molecular Weight
748.91 (free base)
References & Citations
[1]Chinmaya Panda, et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cell. 2021 Jun 30;10 (7) :1652.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC941775-100 1x 100 µL
CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) (CFTR/1775R), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
PKSH032145-01 10 µg
Recombinant Human Calcitonin/CALCA Protein (His Tag)
Sign In for Pricing
View Details