What is the catalog number for DTP3?

The catalog number for DTP3 is HY-100538.

What sizes are available for DTP3?

DTP3 is available in the following size(s): 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does DTP3 come in?

DTP3 is available in 5 different pack sizes.

DTP3 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DTP3?

DTP3 is manufactured by QuantiMol.

What is the estimated delivery time for DTP3?

Estimated delivery time for DTP3 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DTP3?

The safety data sheet for DTP3 is available here: http://file.medchemexpress.com/batch_PDF/HY-100538/DTP3-SDS-MedChemExpress.pdf.

DTP3

DTP3 TFA is a potent and selective GADD45β/MKK7 inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway[1].

Product Specifications

CAS Number

1809784-29-9

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; JAK

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dtp3.html

Purity

98.45

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(N[C@H](CC1=CC=CC=C1)C(N)=O)[C@H](NC([C@H](NC(C)=O)CC2=CC=C(O)C=C2)=O)CCCNC(N)=N

Molecular Formula

C26H35N7O5

Molecular Weight

525.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Tornatore L, et al. Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7inhibitor and clinical candidate, DTP3. Toxicol Rep. 2019 Apr 19;6:369-379.|[2]Tornatore L, et al. Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors. Cancer Cell. 2014 Oct 13;26 (4) :495-508.