LY-3537982
LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM) .LY-3537982 does not inhibit growth of KRAS G12S/G13C/G12D mutant cells and WT KRAS cells (CI50>10 uM) .LY-3537982 displays high selectivity for proteome-wide cysteine residues was evaluated using competitive chemical proteomics (8866 peptides) .LY3537982 inhibits the growth of subcutaneous EL3187 NSCLC PDX tumors in nude mice in a dose dependent manner.LY3537982 demonstrates robust tumor regression in combination with other agents in KRAS G12C in vivo models.LY3537982 is a promising KRAS G12C inhibitor predicted to deliver > 90% KRAS G12C target occupancy in the clinic.
Product Specifications
CAS Number
2414198-64-2
Purity
0.98
Smiles
ClC1C (C2C=CC (=C3C=2C (C#N) =C (N) S3) F) =C (C=C2C=1OC[C@@]1 ([H]) CN (C (C=C) =O) CN1C2=O) F
Molecular Formula
C23H15CLF2N4O3S
Molecular Weight
500.91
Notes
For research use only.
Available Sizes
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