IRES-J007
IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11) ; significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.
Product Specifications
CAS Number
155514-72-0
Purity
>98%
Smiles
O (C ([H]) ([H]) [H]) C1C ([H]) =C (C ([H]) =C ([H]) C=1C ([H]) ([H]) N1C (C2=C ([H]) C ([H]) =C ([H]) C ([H]) =C2C1=O) =O) OC ([H]) ([H]) [H]
Molecular Formula
C17H15NO4
Molecular Weight
297.3053
Notes
For research use only.
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