MCI-INI-3
MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity) .MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1) .MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells.
Product Specifications
CAS Number
1011366-31-6
Purity
>98%
Smiles
C12=CC (C3=CC=CC=C3) =NN1C (C (OC) =O) =CC (C1=CC=C3OCOC3=C1) =N2
Molecular Formula
C21H15N3O4
Molecular Weight
373.36
Notes
For research use only.
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