6-ECDCA (Obeticholic acid)
Obeticholic Acid (6-ECDCA, INT-747) is a potent semisynthetic FXR agonist (EC50 = 99 nM) that induces IκB-α, KLF-2, and KLF-4 expression. It is widely used in research on metabolic and liver diseases, including studies in vitro and in vivo for hepatic steatosis, fibrosis, inflammation, and insulin resistance.
Product Specifications
CAS Number
459789-99-2
Product Name Alternative
6-Ethylchenodeoxycholic acid; 6-ECDCA
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Purity
>98%
Bioactivity
FXR agonist
Form
Powder
Solubility
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)
Smiles
CC[C@H]1[C@@H] (O) [C@H]2[C@@H]3CC[C@H] ([C@H] (C) CCC (O) =O) [C@@]3 (C) CC[C@@H]2[C@@]2 (C) CC[C@@H] (O) C[C@@H]12
Molecular Formula
C26H44O4
Molecular Weight
420.63
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3α-7α-dihydroxy-6α-ethyl-5ß-cholan-24-oic acid
Available Sizes
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