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(S, R, S) -AHPC TFA

(S, R, S) -AHPC TFA (VHL Ligand 1 TFA) is a VH032-derived compound that recruits the VHL E3 ligase. It serves as a key component in constructing PROTAC degraders, such as those targeting BCR-ABL1, which have demonstrated degradation activity with an IC50 of 1.11 μM in Ba/F3 cell-based assays.

Product Specifications

CAS Number

1631137-51-3

Product Name Alternative

AHPC TFA, (S, R, S) -AHPC, (S, R, S) AHPC TFA, (S, R, S) AHPC TFA, E3 ligase-recruiting Moiety, inhibit, Inhibitor, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, VHL ligand1, VHL ligand-1, VHL ligand 1, VHL ligand 1 TFA, VHL, VH032-NH2, VH032-NH2 TFA

Field of Research

Immunology & Inflammation, Pharmacology & Drug Discovery

Purity

97.99% (May vary between batches)

Smiles

O=C (NCC1=CC=C (C2=C (C) N=CS2) C=C1) [C@H]3N (C ([C@H] (C (C) (C) C) N) =O) C[C@H] (O) C3.O=C (O) C (F) (F) F

Molecular Formula

C24H31F3N4O5S

Molecular Weight

544.59

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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