(S, R, S) -AHPC TFA
(S, R, S) -AHPC TFA (VHL Ligand 1 TFA) is a VH032-derived compound that recruits the VHL E3 ligase. It serves as a key component in constructing PROTAC degraders, such as those targeting BCR-ABL1, which have demonstrated degradation activity with an IC50 of 1.11 μM in Ba/F3 cell-based assays.
Product Specifications
CAS Number
1631137-51-3
Product Name Alternative
AHPC TFA, (S, R, S) -AHPC, (S, R, S) AHPC TFA, (S, R, S) AHPC TFA, E3 ligase-recruiting Moiety, inhibit, Inhibitor, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, VHL ligand1, VHL ligand-1, VHL ligand 1, VHL ligand 1 TFA, VHL, VH032-NH2, VH032-NH2 TFA
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
97.99% (May vary between batches)
Smiles
O=C (NCC1=CC=C (C2=C (C) N=CS2) C=C1) [C@H]3N (C ([C@H] (C (C) (C) C) N) =O) C[C@H] (O) C3.O=C (O) C (F) (F) F
Molecular Formula
C24H31F3N4O5S
Molecular Weight
544.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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