GNF-2
GNF-2 is a potent, selective inhibitor that targets Bcr-Abl through a unique allosteric, non-ATP-competitive mechanism. It is a valuable chemical probe for studying kinase signaling in chronic myeloid leukemia (CML) research, demonstrating activity in both cellular and animal models of the disease.
Product Specifications
CAS Number
778270-11-4
Product Name Alternative
Inhibitor, GNF 2, GNF2, GNF-2, inhibit, non-ATP competitive inhibitor, allosteric, BcrAbl, Bcr-Abl, Bcr-Abl (K562 cell line), Bcr-Abl (SUP-B15 cell line), bone erosion, Ba/F3.p185Y253H, Ba/F3.p210, Ba/F3.p210E255V, SARS coronavirus, SARS-CoV, SARSCoV
Field of Research
Cardiovascular Research, Infectious Disease & Virology, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM) ; Ethanol:18.7 mg/mL (49.96 mM) ; DMSO:37.4 mg/mL (99.91 mM)
Smiles
NC (=O) c1cccc (c1) -c1cc (Nc2ccc (OC (F) (F) F) cc2) ncn1
Molecular Formula
C18H13F3N4O2
Molecular Weight
374.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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