Momelotinib
Momelotinib (CYT387) is a potent and orally bioavailable JAK1/2 inhibitor (IC50: 11 nM/18 nM) that blocks ATP binding, disrupting JAK-STAT signaling. This action leads to inhibited proliferation and induced apoptosis in relevant tumor cells, as demonstrated in cellular and animal models of myeloproliferative neoplasms.
Product Specifications
CAS Number
1056634-68-4
Product Name Alternative
Momelotinib, JAK3, Janus kinase, JAK1, JAK2, JAK, inhibit, LM 1149, LM1149, LM-1149, Inhibitor, Apoptosis, Autophagy, CYT 11387, CYT 387, CYT387, CYT-387, CYT11387, CYT-11387
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.07% (May vary between batches)
Solubility
DMSO:62.5 mg/mL (150.8 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.41 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
O=C (NCC#N) c1ccc (cc1) -c1ccnc (Nc2ccc (cc2) N2CCOCC2) n1
Molecular Formula
C23H22N6O2
Molecular Weight
414.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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