What is the catalog number for Y-27632?

The catalog number for Y-27632 is orb1307291.

What sizes are available for Y-27632?

Y-27632 is available in the following size(s): 5 mg, 1 ml x 10 mM (in DMSO), 10 mg, 25 mg, 50 mg, 100 mg, 200 mg.

How many pack sizes does Y-27632 come in?

Y-27632 is available in 7 different pack sizes.

Y-27632 is currently made to order / not held in immediate stock. Contact us for lead time.

Y-27632

ZY-27632 is a potent, cell-permeable inhibitor of ROCK-I and ROCK-II kinases. It is widely used in vitro to study cytoskeletal dynamics and cell adhesion, and in vivo to investigate its role in apoptosis prevention, such as in isolated prostate progenitor cells.

Product Specifications

CAS Number

146986-50-7

Product Name Alternative

Apoptosis, inhibit, Inhibitor, Y27632, Y-27632, Y 27632, Rho-associated protein kinase, Rho-kinase, Rho-associated kinase, ROK, ROCK2, ROCK1, ROCK

Field of Research

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Purity

99.53% (May vary between batches)

Solubility

DMSO:127.5 mg/mL (515.48 mM) ; H2O:insoluble;10% DMSO+90% Saline:2.48 mg/mL (10.03 mM)

Smiles

C[C@@H] (N) [C@H]1CC[C@@H] (CC1) C (=O) Nc1ccncc1

Molecular Formula

C14H21N3O

Molecular Weight

247.34

References & Citations

Jane In den Birken et al. Investigating the Anticancer Effects of Sulforaphane in an In Vitro Coculture Model of Prostate Cancer Cells with Engineered Heart Tissue ACS Pharmacol Transl Sci, (2025), Nicola Wanner et al. Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming JCI Insight, 11 (5), e190283 (2026)