PPQ-102
PPQ-102 is a potent and selective small-molecule CFTR inhibitor, demonstrating complete blockade of the CFTR chloride channel with an IC50 of 90 nM. This tool compound is widely used in vitro to investigate CFTR function in epithelial physiology and is applied in research models of secretory diarrheas and polycystic kidney disease.
Product Specifications
CAS Number
931706-15-9
Product Name Alternative
Polycystic kidney disease, PPQ102, PPQ-102, PPQ 102, E13.5 embryonic kidneys, Cystic fibrosis transmembrane conductance regulator, CFTR Inhibitor, CFTR, Autophagy, Inhibitor, inhibit
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
≥95% (May vary between batches)
Solubility
DMSO:55 mg/mL (125.43 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.56 mM)
Smiles
Cc1ccc (o1) C1Nc2ccccc2-n2c1c1n (C) c (=O) n (C) c (=O) c1c2-c1ccccc1
Molecular Formula
C26H22N4O3
Molecular Weight
438.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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