1,4-Anthraquinone

1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia[1].

Product Specifications

CAS Number

[635-12-1]

UNSPSC

12352005

Hazard Statement

H302, H361, H372, H410

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-4-anthraquinone.html

Purity

98.0

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=CC(C2=C1C=C3C=CC=CC3=C2)=O

Molecular Formula

C14H8O2

Molecular Weight

208.22

Precautions

H302, H361, H372, H410

References & Citations

[1]Perchellet EM, et al. 1,4-Anthraquinone: an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range as daunorubicin in vitro. Anticancer Drugs. 2000 Jun;11 (5) :339-52.