Val-Cit-PAB-MMAE
Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the protease-cleavable Val-Cit-PAB linker and the cytotoxic payload monomethyl auristatin E (MMAE) . MMAE potently inhibits tubulin polymerization, disrupting mitosis. This conjugate is widely used in ADC research for targeted cancer therapy, enabling the evaluation of drug delivery and efficacy in both in vitro and in vivo models.
Product Specifications
CAS Number
644981-35-1
Product Name Alternative
Auristatin, DrugLinkerConjugatesforADC, Drug-Linker Conjugates for ADC, DrugLinker Conjugates for ADC, inhibit, Inhibitor, Val Cit PAB MMAE, ValCitPABMMAE, Val-Cit-PAB-MMAE
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
99.06% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.45 mM) ; DMSO:49 mg/mL (43.62 mM)
Smiles
CC[C@H] (C) [C@@H] ([C@@H] (CC (=O) N1CCC[C@H]1[C@H] (OC) [C@@H] (C) C (=O) N[C@H] (C) [C@@H] (O) c1ccccc1) OC) N (C) C (=O) [C@@H] (NC (=O) [C@H] (C (C) C) N (C) C (=O) OCc1ccc (NC (=O) [C@H] (CCCNC (N) =O) NC (=O) [C@@H] (N) C (C) C) cc1) C (C) C
Molecular Formula
C58H94N10O12
Molecular Weight
1123.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC042922-100 1x 100 µL
Uroplakin 1A (Urothelial Differentiation Marker) (UPK1A/2922), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TRC-D459100-50MG 50 mg
(2R,3R,4S,5R)-1,2:4,5-Di-O-isopropylidene-3-nonadecanol
Sign In for Pricing
View Details ![SAMSN1 Mouse Monoclonal Antibody [Clone ID: OTI7F5]](https://cdn.genprice.uk/products/937/68dd18ba061270361e908454/imageurl/cf808900.webp)
CF808900 100 µg
SAMSN1 Mouse Monoclonal Antibody [Clone ID: OTI7F5]
Sign In for Pricing
View Details 