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VU0463271

VU0463271 is a potent and selective KCC2 antagonist (IC50 = 61 nM) with >100-fold selectivity over NKCC1 and minimal off-target activity. It is a valuable research tool for investigating KCC2 function in neuronal excitability, synaptic inhibition, and related pathophysiology in both in vitro and in vivo models.

Product Specifications

CAS Number

1391737-01-1

Product Name Alternative

Inhibit, KcsA, KCC2, Inhibitor, N-Cyclopropyl-N- (4-methyl-2-thiazolyl) -2-[ (6-phenyl-3-pyridazinyl) thio]acetamide, VU0463271, VU-0463271, VU 0463271, PotassiumChannel, Potassium Channel

Field of Research

Pharmacology & Drug Discovery

Purity

97.84% (May vary between batches)

Solubility

DMSO:3.83 mg/mL (10.01 mM)

Smiles

Cc1csc (n1) N (C1CC1) C (=O) CSc1ccc (nn1) -c1ccccc1

Molecular Formula

C19H18N4OS2

Molecular Weight

382.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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