W-54011
W-54011 is a potent, non-peptide antagonist of the C5a receptor (C5aR1) . It effectively blocks C5a binding (Ki = 2.2 nM) and inhibits downstream functional responses in human neutrophils, including calcium mobilization, chemotaxis, and ROS generation. This compound is a valuable research tool for studying complement-mediated inflammation in both in vitro and in vivo models.
Product Specifications
CAS Number
405098-33-1
Product Name Alternative
Ca2+, C5a, Ca2+ mobilization, , anaphylatoxin, Complement System, ComplementSystem, complement 5a receptor (C5aR), chemotaxis, Chemotaxis, orally, mobilization, neutrophils, inhibit, inflammatory, Inhibitor, W 54011, W54011, W-54011, Reactive Oxygen Species, ROS
Field of Research
Immunology & Inflammation, Metabolism Research, Signal Transduction
Purity
95.62% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.06 mM) ; DMSO:28 mg/mL (56.79 mM)
Smiles
Cl.COc1ccc2CCCC (C (=O) N (Cc3ccc (cc3) N (C) C) c3ccc (cc3) C (C) C) c2c1
Molecular Formula
C30H37ClN2O2
Molecular Weight
493.08
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
11531126 3x 1.0µg DNA
AGPAT5 CRISPRa sgRNA lentivector (set of three targets)(Rat)
Sign In for Pricing
View Details MBS1882006-01 100 Tests
PE-conjugated Anti-BCMA bispecific antibody (DM4)
Sign In for Pricing
View Details MBS1882006-02 5x 100 Tests
PE-conjugated Anti-BCMA bispecific antibody (DM4)
Sign In for Pricing
View Details 43810116 3x 1.0 µg
Sirt5 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
Sign In for Pricing
View Details