SIM-688
SIM-688 is a selective, orally bioavailable small molecule that inhibits estrogen receptor-mediated NF-κB transcriptional activity, demonstrating an IC50 of 122 nM in HAECT-1 cells. This inhibitor is a valuable research tool for studying inflammatory and oncogenic signaling pathways in both cellular and animal models.
Product Specifications
CAS Number
796854-35-8
Product Name Alternative
Progestogen Receptor, progestogenReceptor, SIM 688, SIM688, NF-κB-luc, NF-κB, NFkB, NF-kB, NFκB, Erα, Estrogen Receptor, EstrogenReceptor
Field of Research
Metabolism Research, Signal Transduction
Purity
99.12% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (5.93 mM) ; DMSO:90 mg/mL (161.69 mM)
Smiles
COc1ccccc1[C@H] (c1cccc2ccccc12) [C@@] (C) (C#N) C (=O) N1CCC (CC1) c1cccc (c1) C (F) (F) F
Molecular Formula
C34H31F3N2O2
Molecular Weight
556.62
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Calponin-1 (CALP), CF594 conjugate, 0.1mg/mL
