WRG-28
WRG-28 is a potent and selective allosteric inhibitor of Discoidin Domain Receptor 2 (DDR2), exhibiting an IC50 of 230 nM. It is a valuable chemical probe for investigating DDR2's role in fibrosis and oncology research, enabling both in vitro biochemical assays and in vivo disease model studies.
Product Specifications
CAS Number
1913291-02-7
Product Name Alternative
Rheumatoid arthritis, WRG 28, WRG28, WRG-28, breast cancer, DiscoidinDomainReceptor, Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor (DDR), 4T1 breast cancer cells, BT549, CAFs, joint destruction, inhibit, Inhibitor, HEK293, DDR2, DDR
Field of Research
Signal Transduction
Purity
97.21% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM) ; DMSO:15 mg/mL (36.55 mM)
Smiles
CCNS (=O) (=O) c1ccc (COc2ccc3nc4ccc (=O) cc4oc3c2) cc1
Molecular Formula
C21H18N2O5S
Molecular Weight
410.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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