ACBI1
ACBI1 is a potent VHL-based PROTAC that selectively degrades SMARCA2, SMARCA4, and PBRM1 with low nanomolar DC50 values. It demonstrates anti-proliferative and pro-apoptotic activity in cellular models like MV-4-11, making it a valuable chemical probe for studying chromatin remodeling and oncology research.
Product Specifications
CAS Number
2375564-55-7
Product Name Alternative
Inhibit, Inhibitor, DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1), EpigeneticReaderDomain, Epigenetic Reader Domain, anti-proliferative, Apoptosis, ACBI 1, ACBI1, ACBI-1, PROTAC, PROTACs
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
97.54% (May vary between batches)
Solubility
DMSO:100 mg/mL (106.83 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (4.27 mM)
Smiles
NC1=C (C=C (N=N1) C2=C (O) C=CC=C2) N3CCN (CC4=CC=C (OCCOC5=C (CNC (=O) [C@H]6N (C ([C@@H] (NC (=O) C7 (F) CC7) C (C) (C) C) =O) C[C@H] (O) C6) C=CC (=C5) C8=C (C) N=CS8) C=C4) CC3
Molecular Formula
C49H58FN9O7S
Molecular Weight
936.1
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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