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ZM 306416

ZM 306416 (CB 676475) is a potent small molecule inhibitor of EGFR with an IC50 below 10 nM and also targets VEGFR1 (IC50: 0.33 μM) . This dual-activity compound is a valuable research tool for investigating angiogenesis and tumor growth pathways in both cellular and animal models of cancer.

Product Specifications

CAS Number

690206-97-4

Product Name Alternative

CB676475, CB-676475, CB 676475, BcrAbl, Abl, inhibit, Inhibitor, Src, ZM 306416, ZM306416, ZM-306416, VEGFR1, VEGFR, Vascular endothelial growth factor receptor

Field of Research

Cardiovascular Research, Signal Transduction

Purity

≥95% (May vary between batches)

Solubility

Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.99 mM) ; DMSO:62 mg/mL (185.77 mM)

Smiles

COc1cc2ncnc (Nc3ccc (Cl) cc3F) c2cc1OC

Molecular Formula

C16H13ClFN3O2

Molecular Weight

333.74

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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