ZM 306416
ZM 306416 (CB 676475) is a potent small molecule inhibitor of EGFR with an IC50 below 10 nM and also targets VEGFR1 (IC50: 0.33 μM) . This dual-activity compound is a valuable research tool for investigating angiogenesis and tumor growth pathways in both cellular and animal models of cancer.
Product Specifications
CAS Number
690206-97-4
Product Name Alternative
CB676475, CB-676475, CB 676475, BcrAbl, Abl, inhibit, Inhibitor, Src, ZM 306416, ZM306416, ZM-306416, VEGFR1, VEGFR, Vascular endothelial growth factor receptor
Field of Research
Cardiovascular Research, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.99 mM) ; DMSO:62 mg/mL (185.77 mM)
Smiles
COc1cc2ncnc (Nc3ccc (Cl) cc3F) c2cc1OC
Molecular Formula
C16H13ClFN3O2
Molecular Weight
333.74
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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