ML323
ML323 is a potent and reversible inhibitor of the USP1-UAF1 deubiquitinase complex. It demonstrates activity in biochemical assays with IC50 values of 76 nM (Ub-Rho), 174 nM (K63-diUb), and 820 nM (Ub-PCNA) . This inhibitor is a valuable chemical probe for studying DNA damage response and replication fork stability in cellular and biochemical research.
Product Specifications
CAS Number
1572414-83-5
Product Name Alternative
CID 60167849; NCGC00262306
Field of Research
Protein Biochemistry
Purity
>98%
Bioactivity
USP1-UAF1 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
Smiles
CC (C) c1ccccc1-c1ncc (C) c (NCc2ccc (cc2) -n2ccnn2) n1
Molecular Formula
C23H24N6
Molecular Weight
384.48
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N- (4- (1H-1,2,3-Triazol-1-yl (benzyl) -5-methyl-2- (2-isopropylphenyl) pyrimidin-4-amine
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