SB-203580
Adezmapimod (SB 203580) is a potent, selective, and ATP-competitive p38 MAPK inhibitor (IC50=0.3-0.5 μM) that induces autophagy and mitophagy. It is widely used in vitro and in vivo to study inflammation, stress response, and cell death pathways, demonstrating over 100-fold selectivity against kinases like PKB, LCK, and GSK-3β.
Product Specifications
CAS Number
152121-47-6
Product Name Alternative
Autophagy, ATP-competitive, Adezmapimod, GSK3β, LCK, Mitochondrial Autophagy, Mitophagy, PB 203580, PB203580, PB-203580, Inhibitor, inhibit, RWJ64809, RWJ-64809, RWJ 64809, SAPK2b, SAPK2a, SB 203580, SB203580, SB-203580, PKBα, p38 MAPK, p38MAPK
Field of Research
Immunology & Inflammation, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
P38 MAP kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming) .
Smiles
FC1=CC=C (C2=C (N=C (N2) C3=CC=C (S (C) =O) C=C3) C=4C=CN=CC4) C=C1
Molecular Formula
C21H16N3OSF
Molecular Weight
377.44
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4- (4-fluorophenyl) -2- (4-methylsulfinylphenyl) -5- (4-pyridyl) imidazole
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