Erastin
Erastin is a ferroptosis-inducing compound that activates mitochondrial VDAC channels in a ROS- and iron-dependent manner. It exhibits selective anti-tumor activity against cells harboring RAS mutations and is widely used in vitro and in vivo to study ferroptosis mechanisms and oncogenic signaling in cancer research.
Product Specifications
CAS Number
571203-78-6
Product Name Alternative
Inhibitor, Erastin, Ferroptosis, inhibit, VDAC, Voltage-dependent anion channel
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
97.03% (May vary between batches)
Solubility
DMSO: 25 mg/mL (45.7 mM), Sonication is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) . H2O: < 1 mg/mL (insoluble or slightly soluble) .
Smiles
CCOc1ccccc1-n1c (nc2ccccc2c1=O) C (C) N1CCN (CC1) C (=O) COc1ccc (Cl) cc1
Molecular Formula
C30H31ClN4O4
Molecular Weight
547.04
Storage Conditions
Store at low temperature. Powder: -20°C for 3 years. In solvent: -80°C for 1 year.
Notes
For research use only.
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