GNE-9605
GNE-9605 is a potent and selective brain-penetrant inhibitor of LRRK2 kinase, exhibiting an IC50 of 19 nM. It is a valuable research tool for investigating LRRK2's role in Parkinson's disease, suitable for both cellular assays and in vivo models.
Product Specifications
CAS Number
1536200-31-3
Product Name Alternative
Parkinson's disease, oral bioavailability, LRRK2 Ser1292, LRRK2, inhibit, GNE9605, GNE-9605, GNE 9605, Inhibitor, Leucine-rich repeat kinase 2, autophosphorylation
Field of Research
Cell Biology
Purity
98.55% (May vary between batches)
Solubility
Ethanol:10 mg/mL (22.23 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:82 mg/mL (182.29 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.34 mM)
Smiles
CNc1nc (Nc2cnn ([C@H]3CCN (C[C@@H]3F) C3COC3) c2Cl) ncc1C (F) (F) F
Molecular Formula
C17H20ClF4N7O
Molecular Weight
449.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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