CL2A-SN-38 DCA 1279680-68-0 (free base)
CL2A-SN-38 is a drug-linker conjugate designed for constructing antibody-drug conjugates (ADCs) . It incorporates the topoisomerase I inhibitor SN-38 via a pH-sensitive, non-cleavable CL2A linker, enabling a bystander effect. This conjugate has demonstrated specific and significant antitumor activity in preclinical studies against various human solid tumor models.
Product Specifications
Product Name Alternative
CL2A SN 38 DCA 1279680 68 0 (free base), CL2ASN38 DCA 1279680680 (free base), CL-2A-SN-38 DCA 1279680-68-0 (free base), CL2A-SN-38 DCA 1279680-68-0 (free base)
Purity
98.95% (May vary between batches)
Solubility
DMSO:10 mM
Smiles
OC (=O) C (Cl) Cl.OC (=O) C (Cl) Cl.CCc1c2Cn3c (cc4c (COC (=O) [C@@]4 (CC) OC (=O) OCc4ccc (NC (=O) [C@H] (CCCCN) NC (=O) COCC (=O) NCCOCCOCCOCCOCCOCCOCCOCCOCCn5cc (CNC (=O) C6CCC (CN7C (=O) C=CC7=O) CC6) nn5) cc4) c3=O) -c2nc2ccc (O) cc12
Molecular Formula
C77H101Cl4N11O26
Molecular Weight
1738.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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