Palbociclib (PD0332991)
Palbociclib is an orally bioavailable, potent inhibitor of CDK4 and CDK6 (IC50 11/16 nM) with anti-tumor activity. It is widely investigated in preclinical in vitro and in vivo studies for ER-positive, HER2-negative breast cancer and other cyclin D-driven malignancies.
Product Specifications
CAS Number
571190-30-2
Product Name Alternative
PD-332991
Field of Research
Cell Biology, Immunology & Inflammation
Purity
>98%
Bioactivity
CDK4 / CDK6 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 2 mg/ml with warming)
Smiles
O=C1N (C=2C (C (C) =C1C (C) =O) =CN=C (NC3=CC=C (C=N3) N4CCNCC4) N2) C5CCCC5
Molecular Formula
C24H29N7O2
Molecular Weight
447.53
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-piperazin-1-yl) pyridine-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
Available Sizes
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