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Tazemetostat

Tazemetostat (EPZ6438) is a potent, selective, and orally bioavailable SAM-competitive inhibitor of the EZH2 histone methyltransferase (IC50=11 nM) . It demonstrates antitumor efficacy in preclinical models and is used in research for cancers like epithelioid sarcoma and follicular lymphoma, supporting both in vitro and in vivo experimental studies.

Product Specifications

CAS Number

1403254-99-8

Product Name Alternative

EPZ-6438

Field of Research

Cancer Biology, Epigenetics & Chromatin, Stem Cell & Developmental Biology

Purity

>98%

Bioactivity

EZH2 inhibitor

Form

Powder

Solubility

Soluble in DMSO (up to at least 25 mg/ml)

Smiles

CCN (C1CCOCC1) c1cc (cc (C (=O) NCc2c (C) cc (C) [nH]c2=O) c1C) -c1ccc (CN2CCOCC2) cc1

Molecular Formula

C34H44N4O4

Molecular Weight

572.8

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

N-[ (1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl) methyl]-5-[ethyl (tetrahydro-2H-pyran-4-yl) amino]-4-methyl-4'- (4-morpholinylmethyl) -[1,1'-biphenyl]-3-carboxamide

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