Voruciclib
Voruciclib is a potent and selective orally bioavailable CDK inhibitor, with particular activity against CDK9 (Ki values 0.626-9.1 nM) . It suppresses MCL-1 expression and has demonstrated efficacy in both in vitro and in vivo models of diffuse large B-cell lymphoma (DLBCL) .
Product Specifications
CAS Number
1000023-04-0
Product Name Alternative
Inhibitor, MCL-1, large, multiple, inhibit, orally, models, lymphoma, B-cell, clinical, CDK1/cyc A, CDK1/cycB, CDK1/CyclinB, CDK, CDK9, CDK9/cyc T2, CDK9/CycT1, CDK9/CycT2, CDK4/Cyc D1, CDK6/cycD1, Cyclin dependent kinase, DLBCL, diffuse, stage, Voruciclib
Field of Research
Cell Biology
Purity
99.89% (May vary between batches)
Solubility
DMSO:42.5 mg/mL (90.46 mM)
Smiles
CN1CC[C@H] ([C@@H]1CO) c1c (O) cc (O) c2c1oc (cc2=O) -c1ccc (cc1Cl) C (F) (F) F
Molecular Formula
C22H19ClF3NO5
Molecular Weight
469.84
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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