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7-Chlorokynurenic acid

7-Chlorokynurenic acid is a selective NMDA receptor glycine site antagonist (IC50 = 0.56 μM) and a glutamate reuptake inhibitor (Ki = 0.59 μM) . It is widely used in neuroscience research to study excitatory neurotransmission, neuropathic pain mechanisms, and has demonstrated antinociceptive effects in animal models following central administration.

Product Specifications

CAS Number

18000-24-3

Product Name Alternative

Reuptake of glutamate, NMDA receptor, Glycine B coagonist site of NMDA receptor, Glutamate receptor, 7-chloro-4-hydroxy-2-carboxyquinoline, 7-Chlorokynurenic acid, 7-CKA

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purity

98.83% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.47 mM) ; DMSO:15 mg/mL (67.08 mM)

Smiles

OC (=O) c1cc (O) c2ccc (Cl) cc2n1

Molecular Formula

C10H6ClNO3

Molecular Weight

223.61

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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