7-Chlorokynurenic acid
7-Chlorokynurenic acid is a selective NMDA receptor glycine site antagonist (IC50 = 0.56 μM) and a glutamate reuptake inhibitor (Ki = 0.59 μM) . It is widely used in neuroscience research to study excitatory neurotransmission, neuropathic pain mechanisms, and has demonstrated antinociceptive effects in animal models following central administration.
Product Specifications
CAS Number
18000-24-3
Product Name Alternative
Reuptake of glutamate, NMDA receptor, Glycine B coagonist site of NMDA receptor, Glutamate receptor, 7-chloro-4-hydroxy-2-carboxyquinoline, 7-Chlorokynurenic acid, 7-CKA
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.83% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.47 mM) ; DMSO:15 mg/mL (67.08 mM)
Smiles
OC (=O) c1cc (O) c2ccc (Cl) cc2n1
Molecular Formula
C10H6ClNO3
Molecular Weight
223.61
Storage Conditions
-20°C
Notes
For research use only.
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