A 1070722
A 1070722 is a potent, selective, and brain-penetrant dual inhibitor of GSK-3α/β (Ki = 0.6 nM) . Its ability to cross the blood-brain barrier makes it a valuable chemical tool for in vitro biochemical assays and in vivo research, including potential development as a PET tracer for CNS target engagement studies.
Product Specifications
CAS Number
1384424-80-9
Product Name Alternative
Inhibit, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK-3β, GSK-3α, GSK3, GSK-3, Inhibitor, A 1070722, A1070722, A-1070722
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
99.78% (May vary between batches)
Solubility
DMSO:83.33 mg/mL (230 mM)
Smiles
COc1ccc2c (NC (=O) Nc3cccc (n3) C (F) (F) F) ccnc2c1
Molecular Formula
C17H13F3N4O2
Molecular Weight
362.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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