A-395
A-395 is a potent small molecule antagonist that disrupts the protein-protein interactions within the PRC2 complex, specifically inhibiting the EZH2-EED-SUZ12 trimer with an IC50 of 18 nM. It is a valuable chemical probe for studying PRC2 biology in epigenetic research, applicable in both in vitro biochemical assays and cellular studies.
Product Specifications
CAS Number
2089148-72-9
Product Name Alternative
A 395, A395, A-395, inhibit, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, PRC2
Field of Research
Epigenetics & Chromatin
Purity
97.82% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.05 mM) ; DMSO:100 mg/mL (205.49 mM)
Smiles
CN (C) [C@H]1CN (C[C@@H]1c1ccc (cc1) N1CCN (CC1) S (C) (=O) =O) C1CCc2cccc (F) c12
Molecular Formula
C26H35FN4O2S
Molecular Weight
486.65
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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