A-395
A-395 is a potent small molecule antagonist that disrupts the protein-protein interactions within the PRC2 complex, specifically inhibiting the EZH2-EED-SUZ12 trimer with an IC50 of 18 nM. It is a valuable chemical probe for studying PRC2 biology in epigenetic research, applicable in both in vitro biochemical assays and cellular studies.
Product Specifications
CAS Number
2089148-72-9
Product Name Alternative
A 395, A395, A-395, inhibit, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, PRC2
Field of Research
Epigenetics & Chromatin
Purity
97.82% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.05 mM) ; DMSO:100 mg/mL (205.49 mM)
Smiles
CN (C) [C@H]1CN (C[C@@H]1c1ccc (cc1) N1CCN (CC1) S (C) (=O) =O) C1CCc2cccc (F) c12
Molecular Formula
C26H35FN4O2S
Molecular Weight
486.65
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Explore Other Products
Browse additional items from our catalog
Littman Oxgall Agar Base (Revised as Littman Bile Agar Base)
Phosphatidylinositol glycan anchor biosynthesis, class T
Maged1 sgRNA CRISPR Lentivector (Mouse) (Target 3)
