AMG 487
AMG 487 is a selective small molecule CXCR3 antagonist, potently blocking CXCL10 and CXCL11 binding with IC50 values of approximately 8 nM. It is widely used in research to investigate the role of CXCR3 in autoimmune diseases, transplant rejection, and cancer biology, employing both in vitro binding assays and in vivo disease models.
Product Specifications
CAS Number
473719-41-4
Product Name Alternative
Receptor, cancer, 125I-IP10-CXCR3, 125I-ITAC-CXCR3, AMG 487, AMG487, AMG-487, colon, Breast, chemokine, CXCR3, CXCR, CXC chemokine receptors, CXCL11, CXCL10, Metastatic, metastasis, inhibit, Inhibitor
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
99.82% (May vary between batches)
Solubility
DMSO:41 mg/mL (67.93 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.31 mM)
Smiles
CCOc1ccc (cc1) -n1c (nc2ncccc2c1=O) [C@@H] (C) N (Cc1cccnc1) C (=O) Cc1ccc (OC (F) (F) F) cc1
Molecular Formula
C32H28F3N5O4
Molecular Weight
603.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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