Docetaxel

Docetaxel is a semi-synthetic taxane that stabilizes microtubules, inhibiting their depolymerization with an IC50 of 0.2 μM. It promotes apoptosis by downregulating bcl-2 and bcl-xL, demonstrating potent anti-tumor activity in both cellular assays and animal models for cancer research.

Product Specifications

CAS Number

114977-28-5

Product Name Alternative

Taxotere; RP-56976; NSC-628503

Field of Research

Cell Biology

Purity

>98%

Bioactivity

Microtubule stabilizing agent

Form

Powder

Solubility

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml) .

Smiles

O (C (C) =O) [C@]12[C@]3 ([C@H] (OC (=O) C4=CC=CC=C4) [C@@]5 (O) C (C) (C) C ([C@@H] (O) C (=O) [C@]3 (C) [C@@H] (O) C[C@]1 (OC2) [H]) =C (C) [C@@H] (OC ([C@@H] ([C@@H] (NC (OC (C) (C) C) =O) C6=CC=CC=C6) O) =O) C5) [H]

Molecular Formula

C43H53NO14

Molecular Weight

807.9

References & Citations

Silvia Breusa a b , Eloise Thomas a , Noemi Baldinotti a , Serena Zilio a 1 , Jean-Guy Delcros c , Diana Marcela Hernandez-Palomino d , Weisha Qi e , Hanäé Guérin a , Benjamin Gibert b f , Patrick Mehlen b g , Ilaria Marigo d e , David Kryza a h , Giovanna Lollo Anti-Netrin-1 decorated nanoparticles combined with chemotherapy for the treatment of triple-negative breast cancer Biomaterials Advances, (2024)