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APTO-253

APTO-253 is a small molecule that stabilizes G-quadruplex DNA, leading to c-Myc downregulation and KLF4 tumor suppressor induction. This mechanism results in cell cycle arrest and apoptosis in acute myeloid leukemia (AML) cells, as demonstrated in in vitro studies. Its activity makes it a candidate for oncology research, particularly in hematological malignancies.

Product Specifications

CAS Number

916151-99-0

Product Name Alternative

CMyc, c-Myc, Apoptosis, APTO253, APTO-253, APTO 253, LT253, LT-253, LT 253, inhibit, Myc, KLF, Krüppel-like factor, LOR 253, LOR253, LOR-253, Inhibitor

Field of Research

Cell Biology, Signal Transduction

Purity

98.73% (May vary between batches)

Solubility

DMSO:35.71 mg/mL (97.2 mM)

Smiles

Cc1[nH]c2ccc (F) cc2c1-c1nc2c ([nH]1) c1cccnc1c1ncccc21

Molecular Formula

C22H14FN5

Molecular Weight

367.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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