APTO-253
APTO-253 is a small molecule that stabilizes G-quadruplex DNA, leading to c-Myc downregulation and KLF4 tumor suppressor induction. This mechanism results in cell cycle arrest and apoptosis in acute myeloid leukemia (AML) cells, as demonstrated in in vitro studies. Its activity makes it a candidate for oncology research, particularly in hematological malignancies.
Product Specifications
CAS Number
916151-99-0
Product Name Alternative
CMyc, c-Myc, Apoptosis, APTO253, APTO-253, APTO 253, LT253, LT-253, LT 253, inhibit, Myc, KLF, Krüppel-like factor, LOR 253, LOR253, LOR-253, Inhibitor
Field of Research
Cell Biology, Signal Transduction
Purity
98.73% (May vary between batches)
Solubility
DMSO:35.71 mg/mL (97.2 mM)
Smiles
Cc1[nH]c2ccc (F) cc2c1-c1nc2c ([nH]1) c1cccnc1c1ncccc21
Molecular Formula
C22H14FN5
Molecular Weight
367.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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