Verucerfont

Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.

Product Specifications

CAS Number

[885220-61-1]

Product Name Alternative

GSK561679

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319

Target

CRFR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Verucerfont.html

Purity

99.93

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

CC[C@H](NC1=CC(C)=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN12)C4=NC(C)=NO4

Molecular Formula

C22H26N6O2

Molecular Weight

406.48

Precautions

H302, H312, H315, H319

References & Citations

[1]Schwandt ML, et al. The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects. Neuropsychopharmacology. 2016 Nov;41 (12) :2818-2829.